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:''Not to be confused with the cells of the islets of Langerhans, found in the pancreas, or Langhans giant cell.'' Langerhans cells are dendritic cells (antigen-presenting immune cells) of the skin and mucosa, and contain large organelles called Birbeck granules. They are present in all layers of the epidermis, but are most prominent in the stratum spinosum. They also occur in the papillary dermis, particularly around blood vessels,〔 as well as in the mucosa of the mouth, foreskin, and vagina.〔 They can be found in other tissues, such as lymph nodes, particularly in association with the condition Langerhans cell histiocytosis (LCH). ==Function== In skin infections, the local Langerhans cells take up and process microbial antigens to become fully functional antigen-presenting cells. Generally, dendritic cells in tissue are active in the capture, uptake and processing of antigens. Once dendritic cells arrive in secondary lymphoid tissue, however, they lose these properties while gaining the capacity to interact with naive T-cells. Langerhans cells derive from the cellular differentiation of monocytes with the marker "Gr-1" (also known as "Ly-6G"). This differentiation requires stimulation by colony stimulating factor (CSF)-1. They are similar in morphology and function to macrophages. Langerin is a protein found in Langerhans cells, and other types of dendritic cells. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Langerhans cell」の詳細全文を読む スポンサード リンク
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